Présentation réalisée par Arnaud LE GUILLOU sous la direction du docteur Nicolas COURTIN sur l’utilisation des AINS en péri-opératoire.

Le résumé de la présentation très complet et exhaustif basé sur la dernière revue de la SFAR.

AINS-en-peri-operatoire-topo-10_2023

Le diaporama :

Biblio-AINS_102023Télécharger

Références:

  1. Cyril QUEMENEUR, Hélène BATOZ, Julie GAUME pour le Comité Douleur-ALR. Réponse de la Société Française d’Anesthésie Réanimation (SFAR) suite à la demande de l’Agence Nationale de
    Sécurité du Médicament et des produits de santé (ANSM) sur la prescription des Antiinflammatoires non stéroïdiens (AINS) vis à vis du risque infectieux en anesthésie et en réanimation. AINS pour la gestion de l’analgésie péri-opératoire. Novembre 2023. https://sfar.org/ains-pour-la-gestion-de-lanalgesie-peri-operatoire
  2. Fitzgerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Eng J Med, 2001 ; 345 : 433-442
  3. Understanding the Opioid Overdose Epidemic | Opioids | CDC [Internet]. 2023
  4. Kasper Højgaard Thybo; Daniel Hägi-Pedersen; Jørgen Berg Dahl; et al. Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine
    Consumption in the First 24 Hours After Total Hip Arthroplasty. The PANSAID Randomized Clinical Trial. JAMA. 2019;321(6):562-571
  5. McDaid, C., et al., Paracetamol and selective and non-selective non-steroidal antiinflammatory drugs (NSAIDs) for the reduction of morphine-related side effects after major surgery: a systematic review. Health Technol Assess, 2010. 14(17): p. 1-153, iii-iv.
  6. Elia N, Lysakowski C, Tramèr MR: Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia
    morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology 2005; 103:1296–304
  7. Martinez V, Beloeil H, Marret E, Fletcher D, Ravaud P, Trinquart L. Non-opioid analgesics in adults after major surgery: systematic review with network meta-analysis of randomized Br J Anaesth.
    janv 2017;118(1):22‑31
  8. H Beloeil, P Albaladejo, A Sion, M Durand, V Martinez, S Lasocki, E Futier et al.; OCTOPUS group. Multicentre, prospective, double-blind, randomised controlled clinical trial comparing different
    non-opioid analgesic combinations with morphine for postoperative analgesia: the OCTOPUS study. Br J Anaesth. 2019 Jun;122(6):e98-e106.
  9. Carter JA, Black LK, Sharma D, Bhagnani T, Jahr Efficacy of non-opioid analgesics to control postoperative pain: a network meta-analysis. BMC Anesthesiol. 27 oct 2020;20(1):272.
  10. Stavros G. Memtsoudis, M.D., Ph.D., F.C.C.P.; Jashvant Poeran, M.D., Ph.D.; Nicole Zubizarreta, M.P.H.; Crispiana Cozowicz, M.D.; Eva E. Mörwald, M.D.; Edward R. Mariano, M.D., M.A.S.; Madhu
    Mazumdar, Ph.D. Association of Multimodal Pain Management Strategies with Perioperative Outcomes and Resource Utilization: A Population-based Study. Anesthesiology May 2018, Vol. 128,
    891–902
  11. Frédéric Aubrun, Karine Nouette Gaulain, Dominique Fletcher, Anissa Belbachir, Hélène Beloeil, Michel Carles, Philippe Cuvillon, Christophe Dadure, Gilles Lebuffe, Emmanuel Marret, Valéria Martinez, Michel Olivier, Nadia Sabourdin, Paul Zetlaoui. Réactualisation de la recommandation sur la douleur postopératoire. SFAR. Anesth Reanim. 2016; 2: 421–430
  12. Hyland SJ, Brockhaus KK, Vincent WR, Spence NZ, Lucki MM, Howkins MJ, et al. Perioperative Pain Management and Opioid Stewardship: A Practical Guide. Healthcare. mars 2021;9(3):333
  13. Grams ME, Sang Y, Coresh J, Ballew S, Matsushita K, Molnar MZ, Szabo Z, Kalantar-Zadeh K, Kovesdy CP: . Acute kidney injury after major surgery: A retrospective analysis of Veterans Health Administration data. Am J Kidney Dis . 2016; 67:872–80
  14. Hoste E.A.J., Bagshaw S.M., Bellomo R., Cely C.M., Colman R., Cruz D.N., et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study Intensive Care Med 2015
    ; 41 : 1411-1423
  15. M E O’Connor, R W Hewson, C J Kirwan, G L Ackland, R M Pearse, J R Prowle. Acute kidney injury and mortality 1 year after major non-cardiac surgery. Br J Surg. 2017 Jun;104(7):868-876
  16. Sam D. Gumbert, M.D.; Felix Kork, M.D., M.Sc.; Maisie L. Jackson, M.D.; Naveen Vanga, M.D.; Semhar J. Ghebremichael, M.D.; Christy Y. Wang, M.D.; Holger K. Eltzschig, M.D., Ph.D. Perioperative Acute Kidney Injury. Anesthesiology January 2020, Vol. 132, 180–204
  17. Carole Ichai, Christophe Vinsonneau, Bertrand Souweine et al. Insuffisance rénale aiguë en périopératoire et en réanimation (à l’exclusion des techniques d’épuration extrarénale). SFAR, SRLF, GFRUP, SFN. Anesth Reanim. 2016; 2: 184–205
  18. Martinez V, Fletcher D. Quels sont les véritables bénéfices et risques des AINS et des coxibs chez le sujet âgé ? In: Aubrun F, ed. Anesthésie, analgésie et réanimation du patient âgé Paris: Editions
    Arnette, 2008:409-23
  19. Lee A., Cooper M.G., Craig J.C., Knight J.F., Keneally J.P. Effects of nonsteroidal anti-inflammatory drugs on postoperative renal function in adults with normal renal function. Cochrane Database Syst Rev 2007
  20. Bainbridge D., Cheng D.C., Martin J.E., Novick R. NSAID-analgesia, pain control and morbidity in cardiothoracic surgery Can J Anaesth J Can Anesth 2006 ; 53 : 46-59
  21. Samira Bell, Trijntje Rennie, Charis A Marwick, Peter Davey, and Cochrane Kidney and Transplant Group. Effects of peri‐operative nonsteroidal anti‐inflammatory drugs on post‐operative kidney
    function for adults with normal kidney function. Cochrane Database Syst Rev. 2018
  22. STARSurg Collaborative. Perioperative Nonsteroidal Anti-inflammatory Drugs (NSAID) Administration and Acute Kidney Injury (AKI) in Major Gastrointestinal Surgery: A Prospective, Multicenter, Propensity Matched Cohort Study. Ann Surg. 2022 May 1;275(5):904-910
  23. Dvirnik N, Belley-Cote EP, Hanif H, Devereaux PJ, Lamy A, Dieleman JM, et al. Steroids in cardiac surgery: a systematic review and meta-analysis. Br J Anaesth 2018;120:657–67
  24. Riggin, L., et al., A 2013 updated systematic review & meta-analysis of 36 randomized controlled trials; no apparent effects of non steroidal anti-inflammatory agents on the risk of bleeding after
    tonsillectomy. Clin Otolaryngol, 2013. 38(2): p. 115-29.
  25. Lewis, S.R., et al., Nonsteroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy. Cochrane Database Syst Rev, 2013. 7: p. CD003591.
  26. Kolb CM, Jain N, Schillinger K, Born K, Banker K, Aaronson NL, et Does perioperative ketorolac increase bleeding risk after intracapsular tonsillectomy? Int J Pediatr Otorhinolaryngol. août 2021;147:110781.
  27. Patel NK, Shah SJ, Lee NK, Gao Q, Carullo VP, Yang CJ. Intraoperative intravenous ibuprofen use is not associated with increased post-tonsillectomy Int J Pediatr Otorhinolaryngol. juin 2020;133:109965.
  28. John D Cramer, Michael L Barnett, Samantha Anne, Brian T Bateman, Richard M Rosenfeld, David E Tunkel, Michael J Brenner.Nonopioid, Multimodal Analgesia as First-line Therapy After Otolaryngology Operations: Primer on Nonsteroidal Anti-inflammatory Drugs (NSAIDs). Otolaryngol Head Neck Surg. 2021 Apr;164(4):712-719
  29. Walker NJ, Jones VM, Kratky L, et al.Hematoma risks of nonsteroidal anti-inflammatory drugs used in plastic surgery procedures: a systematic review and meta-analysis. Ann Plast Surg. 2019;826S
    Suppl 5S437–S445
  30. Bongiovanni, Tasce MD, MPP; Lancaster, Elizabeth MD; Ledesma, Yeranuí MD; Whitaker, Evans MD, MLIS; Steinman, Michael A. MD; Allen, Isabel Elaine PhD; Auerbach, Andrew MD, MPH; Wick, Elizabeth MD, FACS. Systematic Review and Meta–Analysis of the Association Between Non– Steroidal Anti–Inflammatory Drugs and Operative Bleeding in the Perioperative Period. Journal of the American College of Surgeons 232(5):p 765-790e1, May 2021
  31. Bellis, J.R., et al., Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis. Br J Anaesth, 2014. 113(1): p. 23-42
  32. Topol EJ. Arthritis medicines and cardiovascular events. « House of coxibs »… JAMA 2005 ; 293 : 366-8. 4.
  33. Fitzgerald GA. Coxib and cardiovascular disease. N Engl J Med 2004 ; 351 : 1709-11
  34. Garcia-Rodriguez L.A., Taconelli S., Prastignani P. Role of dose potency in the prediction of risk of myocardial infarction associated with non-steroidal anti-inflammatory drugs in general population
    J Am Coll Cardiol. 2008 ; 52 : 1628-1636
  35. Solomon, S.D., et al., Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med, 2005. 352(11): p. 1071-80. 17.
  36. Graham, D.J., et al., Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal antiinflammatory drugs: nested case-control study. Lancet, 2005. 365(9458): p. 475-81.
  37. Kearney, P.M., et al., Do selective cyclo-oxygenase-2 inhibitors and traditional nonsteroidal antiinflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ, 2006. 332(7553): p. 1302-8. 19.
  38. McGettigan, P. and D. Henry, Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA, 2006. 296(13): p. 1633-44
  39. Timothy D Warner, Jane A Mitchell. COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs. Lancet. 2008 Jan 19;371(9608):270-3
  40. TD Warner, F Giuliano, I Vojnovic, A Bukasa, JA Mitchell, JR Vane. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA, 96 (1999), pp. 7563-7568.3
  41. A Van Hecken, JI Schwartz, M Depre, et al. Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol, 40 (2000), pp. 1109-1120
  42. Morten Schmidt et al. Diclofenac use and cardiovascular risks: series of nationwide cohort studies, BMJ 2018;362 doi
  43. Scott P.A., Kingsley G.H., Scott D.L. Non-steroidal anti-inflammatory drugs and cardiac failure: meta-analyses of observational studies and randomized controlled trials Eur J Heart Fail. 2008 ; 10 : 1102-1107
  44. Fournier J.P., Sommet A., Bourrel R., Oustric S., Pathak A., Lapeyre-Mestre M., Montastruc J.L. Nonsteroidal anti-inflammatory drugs and hypertension treatment intensification: a population-based cohort study Eur J Clin Phamacol. 2012 ; 68 (11) : 1533-1540
  45. Gislason, G.H., et al., Increased mortality and cardiovascular morbidity associated with use of nonsteroidal anti-inflammatory drugs in chronic heart failure. Arch Intern Med, 2009. 169(2): p.
    141-9. 23.
  46. Coxib And Traditional Nsaid Trialist’s Collaboration Vascular and upper gastro intestinal effects of NSAIDs:meta-analyses of individual participant data from randomized trials Lancet 2013 ; 382 : 769-779
  47. Sherve K., Gerard C.J., Neher J.O., St Anna L. Cardiovascular effects of NSAIDs Am Fam Physician 2014 ; 90 (4)
  48. Krijthe, B.P., et al., Non-steroidal anti-inflammatory drugs and the risk of atrial fibrillation: a population-based follow-up study. BMJ Open, 2014. 4(4): p. e004059
  49. Schjerning Olsen et al. Duration of treatment with nonsteroidal anti-inflammatory drugs and impact on risk of death and recurrent myocardial infarction in patients with prior myocardial infarction: a nationwide cohort study. Circulation. 2011 May 24;123(20):2226-35
  50. Dong Oh Kang, Hyonggin An, Geun U Park, and al. Cardiovascular and Bleeding Risks Associated With Nonsteroidal Anti-Inflammatory Drugs After Myocardial Infarction. J Am Coll Cardiol. 2020
    Aug 4;76(5):518-529
  51. Nussmeier NA, Whelton AA, Brown MT, Langford RM, Hoeft A, Parlow JL, et al. Complications of the COX‐2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med 2005; 352: 1081–
    91
  52. De Souza Brito F, Mehta RH, Lopes RD, Harskamp RE, Lucas BD, Schulte PJ, et al. Nonsteroidal AntiInflammatory Drugs and Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Surgery.
    Am J Med 2017;130:4628.
  53. Javaherforooshzadeh F, Abdalbeygi H, Janatmakan F, Gholizadeh B. Comparing the effects of ketorolac and Paracetamol on postoperative pain relief after coronary artery bypass graft surgery.
    A randomized clinical trial. J Cardiothorac Surg 2020;15:80
  54. Nussmeier, N.A., et al., Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery. Anesthesiology, 2006. 104(3): p. 518-26.
  55. Schug, S.A., et al., Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the postoperative setting: an analysis of integrated data. Anesthesia Analgesia, 2009.
    108(1): p. 299-307
  56. Liu SS, Bae JJ, Bieltz M, Ma Y, Memtsoudis S. Association of perioperative use of nonsteroidal antiinflammatory drugs with postoperative myocardial infarction after total joint replacement. Reg Anesth Pain Med 2012;37:45–50
  57. Gan TJ, Singla N, Daniels SE, et al. Cardiovascular safety of hydroxypropyl-β-cyclodextrin-diclofenac in the management of acute postsurgical pain: A pooled analysis of 2 randomized, double-blind, placebo- and active comparator-controlled phase III clinical trials. J Clin Anesth. 2016;31:249-258
  58. Beattie, W.S., et al., The addition of continuous intravenous infusion of ketorolac to a patientcontrolled analgetic morphine regime reduced postoperative myocardial ischemia in patients undergoing elective total hip or knee arthroplasty. Anesth Analg, 1997. 84(4): p. 715-22
  59. Bryant AE, Bayer CR, Aldape MJ, Stevens DL: The roles of injury and nonsteroidal anti-inflammatory drugs in the development and outcomes of severe group A streptococcal soft tissue Curr Opin
    Infect Dis 2015; 28:231–9
  60. Mikaeloff. Nonsteroidal anti‐inflammatory drug use and the risk of severe skin and soft tissue complications in patients with varicella or zoster disease. 2008 – British Journal of Clinical
    Pharmacology – Wiley Online Library
  61. CRPV de Tours et CRPV de Marseille. Rapport d’expertise – Infections bactériennes graves (de la peau et des tissus mous, pleuro-pulmonaires, neurologiques et ORL) rapportées avec l’ibuprofène ou le kétoprofène dans le traitement symptomatique de la fièvre ou de douleur non rhumatologique. 2019
  62. ANSM. Anti-inflammatoires non stéroïdiens (AINS) et complications infectieuses graves – Point d’information. https://www.ansm.sante.fr/S-informer/Points-d-information-Points-d- information/Anti-inflammatoires-non-steroidiens-AINS-et-complications-infectieuses-gravesPoint-d-Information
  63. Le Bourgeois M, Ferroni A, Leruez-Ville M, Varon E, Thumerelle C, Brémont F, et al. Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study. The Journal of Pediatrics. 2016 Aug;175:47-53
  64. Lund LC, Kristensen KB, Reilev M, et al. Adverse outcomes and mortality in users of non-steroidal anti-inflammatory drugs who tested positive for SARS-CoV-2: A Danish nationwide cohort study.
    PLoS Med. 2020;17(9):e1003308
  65. Bruce E, Barlow-Pay F, Short R et al. Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19. J Clin Med. 2020 Aug
    10;9(8):2586.
  66. Abu Esba LC, Ali Alqahtani R, Thomas A et al. Ibuprofen and NSAID Use in COVID-19 Infected Patients Is Not Associated with Worse Outcomes: A Prospective Cohort Study. Infect Dis Ther. 2020 Nov 2;1-16. Online ahead of print
  67. Jeong HE, Lee H, Shin HJ et al. Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: A nationwide study. Clin Infect Dis. 2020 Jul 27;ciaa1056. Online ahead of print
  68. GA. Fitzgerald. Misguided drug advice for COVID-19. Science. 2020 Mar 27;367(6485):1434
  69. Alice Blet, Lionel Velly, Etienne Gayat, Audrey De Jong, et al. Préconisations pour l’adaptation de l’offre de soins en anesthésie-réanimation dans le contexte de pandémie de COVID-19 / Version Avril 2022. Recommandations de Pratiques Professionnelles de la SFAR en collaboration avec avec les sociétés : ADARPEF, ANARLF, CARO, SF2H, SFC, SFR, SPILF
  70. P. Little. Non-steroidal anti-inflammatory drugs and covid-19. BMJ 2020; 368 :m1185
  71. Lepelletier D., Pinaud V., Le Conte P., et al. Peritonsillar abscess (PTA): clinical characteristics, microbiology, drug exposures and outcomes of a large multicenter cohort survey of 412 patients hospitalized in 13 French university hospitals Eur J Clin Microbiol Infect Dis 2017 ; 36 : 57-63
  72. Emmanuel Besnier, CHU de Rouen. Utilisation des AINS en situation de douleur aiguë et fièvre dans les situations des patients de soins critiques. Réponse de la Société Française d’Anesthésie Réanimation (SFAR) suite à la demande par l’Agence Nationale de Sécurité du Médicament et des produits de santé (ANSM) sur la prescription des Anti-inflammatoires non stéroïdiens (AINS) vis à vis du risque infectieux en anesthésie et en réanimation. Novembre 2023
  73. Nicot R, Hippy C, Hochart C, Wiss A, Brygo A, Gautier S, et Les anti-inflammatoires aggravent-ils les cellulites faciales d’origine dentaire ? Rev Stomatol Chir Maxillo-Faciale Chir Orale. 1 nov 2013;114(5):304‑9
  74. Khouly I, Braun RS, Ordway M, Alrajhi M, Fatima S, Kiran B, et al. Post-operative pain management in dental implant surgery: a systematic review and meta-analysis of randomized clinical trials. Clin Oral Investig. mai 2021;25(5):2511‑36.
  75. Miller CS, Oyler Post-operative pain management in dental implant surgery should consider nonsteroidal anti-inflammatory drugs as best practice. J Oral Maxillofac Anesth [Internet]. 30 sept 2022
  76. Qazi SM, Sindby EJ, Nørgaard MA. Ibuprofen – a Safe Analgesic During Cardiac Surgery Recovery? A Randomized Controlled J Cardiovasc Thorac Res. 2015;7(4):141‑8.
  77. Peng F, Liu S, Hu Y, Yu M, Chen J, Liu Influence of perioperative nonsteroidal anti- inflammatory drugs on complications after gastrointestinal surgery: A meta-analysis. Acta Anaesthesiol Taiwan. 1 déc 2016;54(4):121‑8
  78. Schug, S.A. Do NSAIDs Really Interfere with Healing after Surgery? J Clin Med. 27 mai 2021;10(11):2359
  79. Naseem HUR, Dorman RM, Ventro G, Rothstein DH, Vali K. Safety of perioperative ketorolac administration in pediatric appendectomy. J Surg Res. oct 2017;218:232‑6
  80. Fransen M, Neal B. Non-steroidal anti-inflammatory drugs for preventing heterotopic bone formation after hip arthroplasty. Cochrane Database Syst Rev 2004:CD001160
  81. Devin CJ, McGirt MJ. Best evidence in multimodal pain management in spine surgery and means of assessing postoperative pain and functional outcomes. J Clin Neurosci Off J Neurosurg Soc juin 2015;22(6):930‑8.
  82. Kurd MF, Kreitz T, Schroeder G, Vaccaro AR. The Role of Multimodal Analgesia in Spine J Am Acad Orthop Surg. avr 2017;25(4):260‑8.
  83. Wheatley B.M., Nappo K.E., Christensen D.L., Holman A.M., Brooks D.I., Potter B.K. Effect of Nsaids on Bone Healing Rates: A Meta-Analysis. J. Am. Acad. Orthop. Surg. 2019;27:e330–e336
  84. Borgeat A., Ofner C., Saporito A., Farshad M., Aguirre J. The effect of nonsteroidal antiinflammatory drugs on bone healing in humans: A qualitative, systematic review. J. Clin. Anesth. 2018;49:92–100
  85. Alfonsi, P., et al., [Guidelines for enhanced recovery after elective colorectal surgery]. Ann Fr Anesth Reanim, 2014. 33(5): p. 370-84
  86. Slim K, Joris J, Beloeil H, Groupe Francophone de Réhabilitation Améliorée après Chirurgie (GRACE). Colonic anastomoses and non-steroidal anti-inflammatory drugs. J Visc août 2016;153(4):269‑75
  87. Arron MNN, Lier EJ, de Wilt JHW, Stommel MWJ, van Goor H, Ten Broek RPG. Postoperative administration of non-steroidal anti-inflammatory drugs in colorectal cancer surgery does not increase anastomotic leak rate; A systematic review and meta-analysis. Eur J Surg Oncol. déc 2020;46(12):2167‑73
  88. Wu CY, Cheng KC, Chen YJ, Lu CC, Lin Risk of NSAID-associated anastomosis leakage after colorectal surgery: a large-scale retrospective study using propensity score matching. Int J Colorectal Dis. mai 2022;37(5):1189‑97.
  89. Safety and efficacy of non‐steroidal anti‐inflammatory drugs to reduce ileus after colorectal surgery – – 2020 – BJS (British Journal of Surgery) – Wiley Online Library
  90. Modasi A, Pace D, Godwin M, Smith C, Curtis NSAID administration post colorectal surgery increases anastomotic leak rate: systematic review/meta-analysis. Surg Endosc. mars 2019;33(3):879‑85.
  91. Chen W, Liu J, Yang Y, Ai Y, Yang Y. Ketorolac Administration After Colorectal Surgery Increases Anastomotic Leak Rate: A Meta-Analysis and Systematic Review. Front Surg. 2022
  92. Chapman SJ, Garner JJ, Drake TM, Aldaffaa M, Jayne DG. Systematic Review and Meta-analysis of Nonsteroidal Anti-inflammatory Drugs to Improve GI Recovery After Colorectal Dis Colon Rectum. févr 2019;62(2):248‑56
  93. Huang Y, Tang SR, Young CJ. Nonsteroidal anti-inflammatory drugs and anastomotic dehiscence after colorectal surgery: a meta-analysis. ANZ J oct 2018;88(10):959‑65
  94. S. Jamjittrong, A. Matsuda, S. Matsumoto, T. Kamonvarapitak, N. Sakurazawa, Y. Kawano, et al. Postoperative non-steroidal anti-inflammatory drugs and anastomotic leakage after gastrointestinal anastomoses: systematic review and meta-analysis. Ann Gastroenterol Surg, 4 (1) (2020), pp. 64-75
  95. EuroSurg Collaborative. Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery. Br J Surg. 2020;107:e161–e169
  96. Irani JL, Hedrick TL, Miller TE, Lee L, Steinhagen E, Shogan BD, et al. Clinical practice guidelines for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surg Endosc. janv 2023;37(1):5‑30
  97. Lirk et al, EJA 2023 : PROSPECT guideline for laparoscopic colorectal surgery: a systematic review and procedure-specific postoperative pain management recommendations. In press
  98. H. Joubert. Ulcères de l’estomac et du duodénum. SNFGE, Société Nationale Française de GastroEntérologie. Mars 2018
  99. Laine L, Curtis SP, Cryer B, Kaur A, Cannon CP. Risk factors for NSAID-associated upper GI clinical events in a long-term prospective study of 34 701 arthritis patients. Aliment Pharmacol Ther 2010;32:1240-8
  100. Bombardier, C. et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. CLASS Study Group. N. Engl. J. Med. 343, 1520–1528, 2 p following 1528 (2000).
  101. Schnitzer, T. J. et al. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. Lancet Lond. Engl. 364, 665–674 (2004)
  102. Strom BL, Berlin JA, Kinman JL, Spitz PW, Hennessy S, Feldman H, et al. Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. A postmarketing surveillance study. JAMA 1996;275:376-82
  103. Wang X, Tian HJ, Yang HK, Wanyan P, Peng YJ. Meta-analysis: cyclooxygenase-2 inhibitors are no better than nonselective nonsteroidal anti-inflammatory drugs with proton pump inhibitors in regard to gastrointestinal adverse events in osteoarthritis and rheumatoid arthritis. European journal of gastroenterology & hepatology 2011;23:876-80
  104. HAS. Bon usage des inhibiteurs de la pompe à protons (IPP). Septembre 2022
  105. A. Ericson, B.A. Kallen, Nonsteroidal anti-inflammatory drugs in early pregnancy, Reprod Toxicol. 15(4) (2001) 371-5
  106. R.K. Hernandez, M.M. Werler, P. Romitti, L. Sun, M. Anderka, Nonsteroidal antiinflammatory drug use among women and the risk of birth defects, Am J Obstet Gynecol. 206(3) (2012) 228.e1- 8.
  107. J.D. Interrante, E.C. Ailes, J.N. Lind, M. Anderka, M.L. Feldkamp, M.M. Werler, L.G. Taylor, J. Trinidad, S.M. Gilboa, C.S. Broussard, Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997-2011, Ann Epidemiol. 27(10) (2017) 645-653.e2
  108. K. Nezvalova-Henriksen, O. Spigset, H. Nordeng, Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study, BJOG. 120(8) (2013) 948-59
  109. M.M. van Gelder, N. Roeleveld, H. Nordeng, Exposure to non-steroidal anti-inflammatory drugs during pregnancy and the risk of selected birth defects: a prospective cohort study, PLoS One 6(7) (2011) e22174
  110. S. Daniel, I. Matok, R. Gorodischer, G. Koren, E. Uziel, A. Wiznitzer, A. Levy, Major malformations following exposure to nonsteroidal antiinflammatory drugs during the first trimester of pregnancy, J Rheumatol. 39(11) (2012) 2163-9. doi: 10.3899/jrheum.120453. Epub 2012 Sep 15.
  111. G.L. Nielsen, H.T. Sorensen, H. Larsen, L. Pedersen, Risk of adverse birth outcome and miscarriage in pregnant users of non-steroidal anti-inflammatory drugs: population based observational study and case-control study, BMJ. 322(7281) (2001) 266-70
  112. K Dathe, AK Fietz, LW Pritchard, S Padberg, S Hultzsch, K Meixner, R Meister, C Schaefer. No evidence of adverse pregnancy outcome after exposure to ibuprofen in the first trimester – Evaluation of the national Embryotox cohort. Reprod Toxicol. 2018 Aug:79:32-38.
  113. Li DK et al. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage. BMJ 2003;327:368.
  114. Nakhai-Pour HR, Broy P, Sheehy O, Bérard A. Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion. Can Med Assoc J. 2011;183:1713–
    1720
  115. M Musu, G Finco, R Antonucci, E Polati, D Sanna, M Evangelista, D Ribuffo, V Schweiger, V Fanos. Acute nephrotoxicity of NSAID from the foetus to the adult. Eur Rev Med Pharmacol Sci. 2011 Dec;15(12):1461-72
  116. Dathe K, Hultzsch S, Pritchard LW, Schaefer C. Risk estimation of fetal adverse effects after short-term second trimester exposure to non-steroidal anti-inflammatory drugs: a literature review. Eur J Clin Pharmacol. 2019;75(10):1347–1353
  117. K Dathe, J Frank, S Padberg, S Hultzsch, E Beck, Christof Schaefer. Fetal adverse effects following NSAID or metamizole exposure in the 2nd and 3rd trimester: an evaluation of the German Embryotox cohort. BMC Pregnancy Childbirth. 2022 Aug 26;22(1):666
  118. Koren G, Florescu A, Costei AM, Boskovic R, Moretti ME. Nonsteroidal antiinflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysis.
    Ann Pharmacother. 2006;40:824–829.
  119. Van Marter LJ, Hernandez-Diaz S, Werler MM, Louik C, Mitchell AA. Nonsteroidal antiinflammatory drugs in late pregnancy and persistent pulmonary hypertension of the newborn.
    Pediatrics. 2013;131:79–87
  120. ANSM. Rappel : Jamais d’AINS à partir du début du 6ème mois de grossesse – Point d’Information. 26/01/2017. Disponible sur : https://ansm.sante.fr/S-informer/Points-dinformation-Points-d information/Rappel-Jamais-d-AINS-apartir-du-debut-du-6eme-mois-degrossesse-Point-d-Information
  121. Pannu N, Nadim MK. An overview of druginduced acute kidney injury. Crit Care Med 2008;36:5216–23
  122. Bentley ML, Corwin HI, Dasta J, et al. Druginduced acute kidney injury in the critically ill adult: recognition and preventive strategies. Crit Care Med 2010;38(Suppl. 6):5169–74
  123. Pr Karim Asehnoune, Dr Frédéric Aubrun, Dr Christophe Aveline, Dr Hélène Beloeil et al. Gestion périopératoire des traitements chroniques et dispositifs médicaux. Anti-infectieux, immunosuppresseurs. Annales Françaises d’Anesthésie et de Réanimation 28 (2009) 1035–1036
  124. Frédéric Aubrun, Christophe Baillard, Jean Baptiste Beuscard, Valérie Billard, Institut Gustave Roussy et al. Anesthésie du sujet âgé : l’exemple de fracture de l’extrémité supérieure du fémur. Anesth Reanim. 2019 ; 5 : 122-138
  125. Davidson, B.L., et al., Bleeding risk of patients with acute venous thromboembolism taking nonsteroidal anti-inflammatory drugs or aspirin. JAMA Intern Med, 2014. 174(6): p. 947-53
  126. Frederik Dalgaard, Hillary Mulder, Daniel M Wojdyla, Renato D Lopes, et al. Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial. Circulation. 2020 Jan 7;141(1):10-20
  127. Catella-Lawson, F., et al., Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med, 2001. 345(25): p. 1809-17.
  128. MacDonald TM, Wei L. Effect of ibuprofen on cardioprotective effect of aspirin. Lancet. 2003;361:573–4
  129. Gladding PA, Webster MWI, Farrell HB, Zeng ISL, Park R, Ruijne N. The antiplatelet effect of six non-steroidal anti-inflammatory drugs and their pharmacodynamic interaction with aspirin in healthy volunteers. Am J Cardiol. 1 avr 2008;101(7):1060‑3
  130. X. Li, S. Fries, R. Li, et al. Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs Proc Natl Acad Sci U S A, 111 (2014), pp. 16830-16835
  131. Schjerning Olsen, A.M., et al., Association of NSAID use with risk of bleeding and cardiovascular events in patients receiving antithrombotic therapy after myocardial infarction. JAMA, 2015. 313(8): p. 805-14
  132. Anne Godie, Pierre Fontana, Serge Motte, Annick Steib et al. French Working Group on perioperative hemostasis (GIHP). Gestion des agents antiplaquettaires pour une procédure invasive programmée. Propositions du Groupe d’intérêt en hémostase périopératoire (GIHP) et du Groupe français d’études sur l’hémostase et la thrombose (GFHT) en collaboration avec la Société française d’anesthésie-réanimation (SFAR). Recommandations formalisées d’experts. Anesthésie & Réanimation, Volume 4, Issue 6, November 2018, Pages 548-562
  133. Alexandra N Colebatch, Jonathan L Marks, Christopher J Edwards. Safety of non‐steroidal anti‐ inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis. Cochrane Database of Systematic Reviews Review – Intervention.
    09 November 2011
  134. https://base-donneespublique.medicaments.gouv.fr/affichageDoc.php?specid=60695745&typedoc=R
  135. Phelan KM, Mosholder AD, Lu S. Lithium interaction with the cyclooxygenase 2 inhibitors rofecoxib and celecoxib and other nonsteroidal anti-inflammatory drugs. J Clin Psychiatry. 2003;64(11):1328–34
  136. Finley PR. Drug Interactions with Lithium: An Update. Clin Pharmacokinet (2016) 55:925–941.], pouvant aller jusqu’à 100% dans certains cas [Jones MT, Stoner SC. Increased lithium concentrations reported in patients treated with sulindac. J Clin Psychiatry. 2000;61(7):527–8
  137. Brater DC. Effects of nonsteroidal anti-inflammatory drugs on renal function: focus on cyclooxygenase-2-selective inhibition. Am J Med. 1999;107(6A):65S–70S
  138. Harris RC. COX-2 and the kidney. J Cardiovasc Pharmacol. 2006;47(Suppl 1):S37–42
  139. Rui Pedro Nunes. Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review. Arc. Clin. Psychiatr. 45 (2). Mar-Apr 2018
  140. https://base-donneespublique.medicaments.gouv.fr/affichageDoc.php?specid=62124478&typedoc=R
  141. https://hoptimal.vidal.fr/medicament/advil_200_mg_cp_enr-364.html#contre_indications
  142. Maddali MM, Kurian E, Fahr J. Extubation time, hemodynamic stability, and postoperative pain control in patients undergoing coronary artery bypass surgery: an evaluation of fentanyl, remifentanil, and nonsteroidal antiinflammatory drugs with propofol for perioperative and postoperative management. J Clin Anesth 2006;18:605–10.
  143. Fayaz MK, Abel RJ, Pugh SC, Hall JE, Djaiani G, Mecklenburgh JS. Opioid-sparing effects of diclofenac and paracetamol lead to improved outcomes after cardiac surgery. J Cardiothorac Vasc Anesth 2004;18:742–7
  144. PM. Mertes, M. Kindo, J. Amour, C. Baufreton, L. Camilleri, et al. Réhabilitation Améliorée Après Chirurgie Cardiaque adulte sous CEC ou à cœur. RFE commune SFAR – SFCTCV 2021.
  145. McCrory C, Diviney D, Moriarty J, Luke D, Fitzgerald D. Comparison between repeat bolus intrathecal morphine and an epidural delivered bupivacaine and fentanyl combination in the management of post thoracotomy pain with or without cyclooxygenase inhibition. J Cardiothorac Vasc Anesth 2002;16:60711.
  146. Boussofara M, Mtaallah MH, Bracco D, Sellam MR, Raucoules M. Co-analgesic effect of ketorolac after thoracic surgery. Tunis Med 2006;84:427–31
  147. Senard M, Deflandre EP, Ledoux D, Roediger L, Hubert BM, Radermecker M, et al. Effect of celecoxib combined with thoracic epidural analgesia on pain after thoracotomy. Br J Anaesth 2010;105:196 200
  148. Zhou M, Li B, Kng M. Effects of Flurbiprofen Axetil on Postoperative Analgesia and Cytokines in Peripheral Blood of Thoracotomy Patients. Cell Biochem Biophys 2015
  149. Pascal Berna, Christophe Quesnel, Jalal Assouad, Patrick Bagan et al. Réhabilitation améliorée après lobectomie pulmonaire. RFE commune SFAR – SFCTCV. 2019
  150. Lardinois D, Vogt P, Yang L, Hegyi I, Baslam M, Weder W. Non-steroidal antiinflammatory drugs decrease the quality of pleurodesis after mechanical pleural abrasion. Eur J Cardio-Thorac Surg Off J Eur Assoc Cardio-Thorac Surg. mai 2004;25(5):865‑71
  151. E Ben Jemia, A Allouche,H Zaibi, B Karaborni, J Ben Amar, H Aouina. Facteurs influencants la durée du drainage thoracique des patients hospitalisés pour pneumothorax. Revue des maladies respiratoires actualités, Volume 4, Issue 1, January 2022, Pages 259-260
  152. Lizardo RE, Langness S, Davenport KP, Kling K, Fairbanks T, Bickler SW, et al. Ketorolac does not reduce effectiveness of pleurodesis in pediatric patients with spontaneous pneumothorax. J Pediatr Surg. déc 2015;50(12):2035‑7.
  153. Ben-Nun A, Golan N, Faibishenko I, Simansky D, Soudack M. Nonsteroidal Antiinflammatory Medications: Efficient and Safe Treatment Following VideoAssisted Pleurodesis for Spontaneous Pneumothorax. World J Surg. nov 2011;35(11):2563‑7
  154. Rima Saaifan. Évaluation rétrospective de l’impact des anti-inflammatoires non stéroïdiens dans la chirurgie du pneumothorax spontané. Médecine humaine et pathologie. 2022. dumas04068905
  155. Leviel F. Etude KETOTHORAX : Impact de la prescription d’anti-inflammatoires non stéroïdiens dans la chirurgie de pleurodèse après pneumothorax : une étude prospective contrôlée randomisée de non-infériorité en double aveugle multicentrique. PHRCI-19-034
  156. Andersen LP, Werner MU, Rosenberg J, Gögenur I. Analgesic treatment in laparoscopic gastric bypass surgery: a systematic review of randomized trials. Obes Surg 2014; 24: 462–470.
  157. Carron M. Safaee Fakhr B. Ieppariello G. Foletto M. Perioperative care of the obese patient. Br J Surg. 2020; 107: e39-55
  158. Hicham Abou Zeid, Rita Kallab, Marie Antoinette Najm, Hisham Jabbour, Roger Noun, Fadi Sleilati, Salim Chucri, Christine Dagher, Ghassan Sleilaty, Nicole Naccache. Safety and Efficacy of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Used for Analgesia After Bariatric Surgery: A Retrospective Case-Control Study. Obes Surg. 2019 Mar;29(3):911-916.
  159. Kamyar Hariri, Elizabeth Hechenbleikner, Matthew Dong, Subhash U Kini, Gustavo FernandezRanvier, Daniel M Herron. Ketorolac Use Shortens Hospital Length of Stay After Bariatric Surgery: a Single Center 5-Year Experience. Obes Surg. 2019 Aug;29(8):2360-2366
  160. Jeffrey I Mechanick, Caroline Apovian, Stacy Brethauer, W Timothy Garvey et al.. Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures – 2019 update: cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic & Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists. Surg Obes Relat Dis. 2020 Feb;16(2):175-2473
  161. Jan Peter Yska, Sanneke Gertsen, Gerbrich Flapper, Marloes Emous, Bob Wilffert, Eric N van Roon. NSAID Use after Bariatric Surgery: a Randomized Controlled Intervention Study. Obes Surg. 2016 Dec;26(12):2880-2885
  162. Begian A, Samaan JS, Hawley L, Alicuben ET, Hernandez A, Samakar K. The use of nonsteroidal anti-inflammatory drugs after sleeve gastrectomy. Surg Obes Relat Dis. 2021; 17(3): 484-488
  163. Martin L Skogar, Magnus Sundbom. Nonsteroid anti-inflammatory drugs and the risk of peptic ulcers after gastric bypass and sleeve gastrectomy. Surg Obes Relat Dis. 2022 Jul;18(7):888-893
  164. Delaunay L., Jenny J.Y., Albi-Feldzer A., et al. Guidelines for enhanced recovery for major orthopaedic surgery (Hip and knee arthroplasties) : SFAR & SOFCOT (2019)
  165. Anna R. Schoenbrunner, Girish P. Joshi and Jeffrey E. Janis. Multimodal Analgesia in the Aesthetic Plastic Surgery: Concepts and Strategies. Plast Reconstr Surg Glob Open. 2022 May; 10(5): e4310
  166. Sun T, Sacan O, White PF, et al.Perioperative versus postoperative celecoxib on patient outcomes after major plastic surgery procedures. Anesth Analg. 2008;106:950–958
  167. Barker JC, DiBartola K, Wee C, et al.Preoperative multimodal analgesia decreases postanesthesia care unit narcotic use and pain scores in outpatient breast surgery. Plast Reconstr Surg. 2018;142:443e–450e
  168. Stephens DM, Richards BG, Schleicher WF, et al.. Is ketorolac safe to use in plastic surgery? A critical review. Aesthet Surg J. 2015;35:462–466
  169. Gupta A, Jakobsson J.Acetaminophen, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 selective inhibitors: an update. Plast Reconstr Surg. 2014;1344 Suppl 224S–31S
  170. Mikhaylov Y, Weinstein B, Schrank TP, et al.Ketorolac and hematoma incidence in postmastectomy implant-based breast reconstruction. Ann Plast Surg. 2018;80:472–474
  171. Firriolo JM, Nuzzi LC, Schmidtberg LC, et al.Perioperative ketorolac use and postoperative hematoma formation in reduction mammaplasty: a single-surgeon experience of 500 consecutive cases. Plast Reconstr Surg. 2018;142:632e–638e
  172. Klifto KM, Elhelali A, Payne RM, et al.. Perioperative systemic nonsteroidal anti-inflammatory drugs (NSAIDs) in women undergoing breast surgery. Cochrane Database Syst Rev. 2021;11:CD013290.
  173. Maureen F. Cooney. Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings. Paediatr Drugs. 2021; 23(4): 361–372
  174. Michelet D., Andreu-Gallien J., Bensalah T., Hilly J., Wood C., Nivoche Y., et al. A meta-analysis of the use of nonsteroidal anti-inflammatory drugs for pediatric postoperative pain Anesth Analg 2012 ; 114 (2) : 393-406
  175. Sara Pessano, Natasha R Gloeck, Luca Tancredi, Martin Ringsten, Ameer Hohlfeld, Sumayyah Ebrahim, Martina Albertella, Tamara Kredo, Matteo Bruschettini. Ibuprofen for acute postoperative pain in children. Cochrane Database Syst Rev. 2024 Jan 5;1(1):CD015432
  176. Ziesenitz VC, Welzel T, van Dyk M, Saur P, Gorenflo M, van den Anker JN. Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Paediatr Drugs. nov 2022;24(6):603‑55
  177. Lesko S.M., Mitchell A.A. An assessment of the safety of pediatric ibuprofen. A practitionerbased randomized clinical trial JAMA 1995 ; 273 (12) : 929-933
  178. Jalkut MK. Ketorolac as an analgesic agent for infants and children after cardiac surgery: safety profile and appropriate patient AACN Adv Crit Care. 2014;25(1):23‑30; quiz 31‑2
  179. Poonai N, Datoo N, Ali S, Cashin M, Drendel AL, Zhu R, et al. Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial. CMAJ. 2017;189(40):E1252–E1258
  180. Collège de la Haute Autorité de santé. Prise en charge médicamenteuse de la douleur chez l’enfant : alternative à la codéine. Rapport d’élaboration : Haute Autorité de santé (HAS) (2016)
  181. Truffert E, Fournier Charrière E, Treluyer JM, Blanchet C, Cohen R, Gardini B, et al. Guidelines of the French Society of Otorhinolaryngology (SFORL): Nonsteroidal anti- inflammatory drugs (NSAIDs) and pediatric ENT Short version. Eur Ann Otorhinolaryngol Head Neck Dis. sept 2019;136(4):289‑94
  182. N. Aldamluji, A. Burgess, E. Pogatzki-Zahn, J. Raeder, H. Beloeil. PROSPECT guideline for tonsillectomy: systematic review and procedure-specific postoperative pain management recommendations. Anaesthesia 2021, 76, 947–961
  183. Kvasnovsky CL, Aujla U, Bjarnason I. Nonsteroidal anti-inflammatory drugs and exacerbations of inflammatory bowel disease. Scand J Gastroenterol 2015;50:255–63.
  184. Bonner GF, Fakhri A, Vennamaneni SR. A long-term cohort study of nonsteroidal antiinflammatory drug use and disease activity in outpatients with inflammatory bowel disease. Inflamm Bowel Dis 2004;10:751–7
  185. Millie D Long, Michael D Kappelman, Christopher F Martin, Wenli Chen, Kristen Anton, Robert S Sandler. Role of Nonsteroidal Anti-Inflammatory Drugs in Exacerbations of Inflammatory Bowel Disease. J Clin Gastroenterol. 2016 Feb;50(2):152-6
  186. O. O. Moninuola, W. Milligan, P. Lochhead, H. Khalili. Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn’s disease and ulcerative colitis exacerbation. Aliment Pharmacol Ther. 2018 Jun; 47(11): 1428–1439
  187. Christopher Andrew Lamb, Nicholas A Kennedy, Tim Raine, et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut. 2019 Dec;68(Suppl 3):s1-s106
  188. Rappel des règles de bon usage des anti-inflammatoires non stéroïdiens (AINS) – Rapport ANSM. 2013 juillet.
  189. Doleman B, Leonardi-Bee J, Heinink TP, Boyd-Carson H, Carrick L, Mandalia R, Lund JN, Williams JP. Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery. Cochrane Database of Systematic Reviews. 14 June 2021